The objective of the current study was to develop and optimize oral disintegrating tablets of rosiglitazone maleate which is an effective drug in the treatment of type II diabetes mellitus. Rosiglitazone maleate containing tablets were prepared by direct compression method using different ingredients such as croscarmellose sodium, crospovidone, potato starch, sodium saccharine, lactose, talc and magnesium stearate. The tablets were evaluated for physical properties including hardness, weight variation, thickness, friability, drug content, in-vitro disintegration time and in-vitro dissolution study. The hardness, weight variation, thickness, friability and drug content of tablets were found to be acceptable according to pharmacopoeial limits. An optimized tablet formulation i.e. F12 was found, which provided short in-vitro disintegration time of 10.14 sec. From the above results, it indicated that the amount of superdisintegrant i.e. crospovidone and croscarmellose sodium was significantly affected the dependent variables like in-vitro disintegration time. The best in-vitro drug release was found to be in F12 98.67% during the end of 60 min.
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